We are pleased to share findings from our recent pilot study published in Advances in Pharmacology and Pharmacy , which provides new insights into the pharmacokinetics of inhaled molecular hydrogen in healthy humans. Molecular hydrogen has emerged as a promising therapeutic gas, with potential applications in a range of acute and chronic conditions. However, despite increasing interest, human data on hydrogen pharmacokinetics remain limited, particularly with respect to optim

After six years of dedicated work, numerous studies, and a series of published papers, our colleague and experimental psychologist Dragana Zanini has successfully defended her doctoral thesis and earned a well-deserved PhD. Dr. Zanini’s research focused on understanding how different nutritional interventions influence molecular and phenotypic biomarkers of aging. Her work has already made a strong impact, with publications in leading journals such as Experimental Gerontology

We are launching a new human study examining changes in circulating dihydrogen levels following single-dose administration in healthy volunteers. This investigation represents the first step within a broader research program aimed at systematically characterizing the pharmacokinetics and pharmacodynamics of molecular hydrogen after exogenous intake. Beyond documenting time-dependent changes in blood hydrogen concentrations, the project seeks to clarify key determinants of pos

Vitamin D deficiency remains common worldwide, even among adults who spend time outdoors or try to eat well. We have launched a new pilot study to better understand how vitamin D status changes over time when intake is carefully controlled and monitored, while everyday sources of vitamin D are taken into account. The study will examine how eight weeks of supplementation with two different vitamin D₃ products will affect vitamin D status in otherwise healthy adults with below-

We are pleased to share that Bogdan Andjelic, our part-time junior researcher and laboratory technician, has successfully completed his PhD program at the University of Palermo on December 11, earning the degree of Doctor of Health Promotion and Cognitive Sciences. Throughout his doctoral training, Dr. Andjelic played an important role in several interventional and observational studies examining creatine metabolism under physiological and psychological stress. His contributi

Our research team is excited to announce the start of a new study ( CONCRET-SARCOPA ) which explores whether a specialized form of creatine (creatine hydrochloride) can improve muscle health, mobility, and cognitive performance in older adults living with sarcopenia, a condition characterized by age-related loss of muscle mass and function. Over a 12-week period, participants will receive either creatine HCl or placebo, and we will evaluate changes in body composition, muscle

On October 17, leading international creatine researchers gathered at the University of Cambridge to honor the late Dr. Roger C. Harris, a pioneering scientist whose groundbreaking studies in the early 1990s laid the foundation for modern creatine research. Dr. Harris, who passed away in December 2024, made seminal contributions to understanding the physiological and metabolic effects of creatine supplementation. The Memorial Symposium provided a meaningful opportunity to ref

In October, Dr. Sergej M. Ostojic had the privilege of delivering two invited presentations on creatine for longevity and female midlife vitality at the Food and Nutrition Conference and Expo (FNCE) 2025, held in Nashville, Tennessee. As one of the largest annual gathering of nutrition professionals in the world, FNCE brought together nearly 10,000 attendees, including dietitians, physicians, nurses, researchers, policymakers, and industry leaders. The event served as a uniqu

A new pilot study from our lab, recently published in the reputable journal Nutrition and Health , suggests that creatine, best known for its role in enhancing muscle energy, may also support male fertility by improving sperm quality In the first clinical trial of its kind, we investigated whether dietary creatine, alone or combined with the antioxidant ubiquinol, could influence the chemical and microscopic properties of human semen. The eight-week randomized, placebo-contro

On September 19, Elsevier and Professor John P. A. Ioannidis released the latest update of the Science-Wide Author Databases of Standardized Citation Indicators —widely known as the Stanford University list of the world’s top 2% of scientists. For the seventh consecutive year, Professor Sergej M. Ostojic has been recognized among this global elite group, reflecting both his sustained research productivity and scientific influence. In the latest edition, he is ranked 6,520th o

Our laboratory has recently launched a randomized controlled trial to investigate the potential benefits of creatine and creatine analogs in older adults. The study aims to determine whether eight weeks of guanidinoacetic acid (GAA) supplementation provides greater improvements than creatine in muscle function and biomarkers of muscle protein synthesis among individuals aged 65 years and older. Preliminary evidence suggests that GAA may have anabolic and anti-catabolic effect

Our group has just published a new paper titled: Association between dietary creatine intake and serum biomarkers of spermatogenesis in males aged 12 years and older , in the latest issue of Reproduction and Fertility, a leading journal in this field! Creatine is a naturally occurring nutrient that helps supply energy to many tissues in the body-including the testes, where sperm are produced. Because sperm development is an energy-demanding process, researchers have long spe

Our team has recently published a new paper that investigated the effects of 8-week creatine hydrochloride and creatine ethyl ester supplementation on cognition, clinical outcomes, and brain creatine levels in perimenopausal and menopausal women in the eminent Journal of the American Nutrition Association. The study investigated whether short-term supplementation with different doses and forms of creatine could improve brain health, cognitive function, and metabolic outcomes