New paper in Nutr Health

A new pilot study from our lab, recently published in the reputable journal Nutrition and Health, suggests that creatine, best known for its role in enhancing muscle energy, may also support male fertility by improving sperm quality

In the first clinical trial of its kind, we investigated whether dietary creatine, alone or combined with the antioxidant ubiquinol, could influence the chemical and microscopic properties of human semen. The eight-week randomized, placebo-controlled study involved 15 healthy men, including five diagnosed with oligospermia (low sperm count). Participants received either creatine, creatine-plus-ubiquinol, or a placebo, and were evaluated for sperm characteristics, biochemical markers, overall well-being, and possible side effects.

Results showed a positive trend toward higher sperm concentrations in men who took creatine-plus-ubiquinol, with an average increase of 7.4 million sperm per milliliter compared to baseline. Sixty percent of participants in the creatine groups (with or without ubiquinol) experienced improved sperm concentration, compared to just 20 percent in the placebo group. Notably, all men with low sperm counts who received creatine-based supplementation showed measurable improvement, while those in the placebo group did not.

The study also revealed a significant 35.8 percent increase in sperm creatine concentration in the creatine-plus-ubiquinol group, indicating enhanced energy metabolism within sperm cells.

“These preliminary findings point to a promising role for creatine-based nutrition in supporting male reproductive health,” we noted, emphasizing that larger and longer-term studies are needed to validate these results.

The study, registered at ClinicalTrials.gov (NCT06202469), marks an important step toward understanding how bioenergetic nutrients like creatine may contribute to fertility optimization in men. The full text is available here: link