Our new paper in JANA

Our team has recently published a new paper that investigated the effects of 8-week creatine hydrochloride and creatine ethyl ester supplementation on cognition, clinical outcomes, and brain creatine levels in perimenopausal and menopausal women in the eminent Journal of the American Nutrition Association.

The study investigated whether short-term supplementation with different doses and forms of creatine could improve brain health, cognitive function, and metabolic outcomes in women undergoing menopause. Specifically, we compared low- and medium-dose creatine hydrochloride, as well as a combination of creatine hydrochloride plus creatine ethyl ester, against a placebo over an 8-week period.

Among 36 perimenopausal and postmenopausal women enrolled, medium-dose creatine hydrochloride was found to significantly improve reaction time, increase frontal brain creatine levels, and favorably influence lipid profiles compared with placebo. It also showed a trend toward reducing the severity of mood swings. All treatments were well tolerated, with no serious side effects reported.

These findings suggest that creatine hydrochloride supplementation may represent a safe, practical, and effective nutritional strategy to support cognitive and metabolic health in midlife women. The full paper is available at the following link.