Mapping the kinetics of circulating hydrogen

We are launching a new human study examining changes in circulating dihydrogen levels following single-dose administration in healthy volunteers. This investigation represents the first step within a broader research program aimed at systematically characterizing the pharmacokinetics and pharmacodynamics of molecular hydrogen after exogenous intake.

Beyond documenting time-dependent changes in blood hydrogen concentrations, the project seeks to clarify key determinants of post-intervention exposure, such as absorption dynamics, peak levels, and clearance profiles. A central objective is to identify threshold concentrations of circulating hydrogen that may be linked to measurable biological effects, thereby moving the field from descriptive observations toward dose-response understanding.

By integrating precise analytical measurements with controlled intervention protocols, this work will provide a mechanistic foundation for future trials exploring the bioenergetic, metabolic, and redox-modulating actions of hydrogen gas. Ultimately, our data might help inform rational dosing strategies and evidence-based applications of molecular hydrogen in both clinical and performance settings.