Dietary creatine and spermatogenesis

Our group has just published a new paper titled: Association between dietary creatine intake and serum biomarkers of spermatogenesis in males aged 12 years and older, in the latest issue of Reproduction and Fertility, a leading journal in this field!

Creatine is a naturally occurring nutrient that helps supply energy to many tissues in the body-including the testes, where sperm are produced. Because sperm development is an energy-demanding process, researchers have long speculated that creatine might influence sperm health.

While some studies have suggested potential benefits, others have raised concerns, leaving the relationship unclear. To shed light on this topic, our team analyzed data from more than 1,300 males in the United States, aged 12 years and older. We examined how much creatine participants consumed through their diet and compared this with blood levels of two key hormones involved in sperm production.

Our analysis found no strong association between dietary creatine intake and reproductive hormone levels. This suggests that creatine obtained from food is unlikely to have a major impact—positive or negative—on male reproductive health.

Since this study relied on existing population data rather than direct experimental testing, further research—particularly studies that directly assess sperm parameters—is needed to clarify creatine’s role in male fertility.

The full text is available at this link.