News
Docking studies on creatine and GAA
Docking studies on creatine and GAA New paper in JCR Our paper on comparative molecular docking studies on creatine and guanidinoacetic acid (GAA) has been published in Journal of Chemical Research. Docking and density functional theory studies are carried out for muscle [...]
New paper in Nutrition Research
New paper in Nutrition Research L-Carnosine effective in MS Our recent study published in Nutrition Research describes the effects of L-carnosine administration on various patient- and clinician-reported outcomes in a case series of patients with multiple sclerosis (MS). L-carnosine was administered orally [...]
Clinical Bioenergetics – 1st Edition
Clinical Bioenergetics | 1st Edition ABL book for Elsevier The book on bioenergetics edited by Professor Ostojic has just been published for Elsevier! Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired [...]
Brain creatine in preterm children
Creatine levels are rather sensitive to numerous conditions of the developing brain, including prematurity-related clinical complications. For instance, the presence of cerebellar injury in infants born prematurely was consistently associated with reduced concentrations of creatine (along with N-acetyl aspartate and choline), while cerebral cortical brain injury severity was inversely associated with both creatine and choline.
Creatine loading for chronic migraine?
A recent research demonstrated an impaired brain metabolism in chronic migraine patients with medication overuse headache. Besides other findings, reduced total creatine levels have been found in the left thalamus of 32 chronic migraine patients with and without medication.
GAA deficiency in clinical medicine
Guanidinoacetic acid (GAA) is a naturally-occurring precursor of creatine and one of the key compounds investigated in our lab. GAA is found in human serum and urine, with circulating GAA likely reflects an equilibrium between its endogenous production and utilization/excretion.
On-Going Research
L-carnosine PK study
We have continued scrutinization of L-carnosine in ABL! This time, we profile the single-dose pharmacokinetics of L-carnosine in healthy men in aim to compare the time course of its absorption, bioavailability, distribution, metabolism and excretion vs. traditional carnosine. The phase 0 study may help us to better determine the half-life of this nutritional additive and perhaps establish the most appropriate dosing regimen.
Kick off for elderly hydrogen trial
Kick off time for another RCT in elderly! This time, we aim to evaluate does 6-month supplementation with magnesium-powered hydrogen-rich water affect molecular and phenotypic biomarkers of aging. This ambitious trial, comprises various biomarkers of aging in men and women over 70 years, such as extensive blood biochemistry panel, brain metabolism, cognitive and physical function, even facial skin features, assessed both before and after the intervention in a magnesium-controlled parallel-group design.
Topical hydrogen in DOMS trial
Topical hydrogen in DOMS trial Questioning post-exercise recovery During the past few days, we started new trial evaluating the effects of topical hydrogen on biomarkers of delayed onset of muscle soreness (DOMS) after exhaustive eccentric exercise in young men. The small-scale double-blind placebo-controlled randomized trial actually tries to find out weather 30-min single-session bathing with super-saturated [...]
Does 8-plant extract affect telomerase activity?
Does 8-plant extract affect telomerase activity? RCT trial in ABL We have started another double-blind RCT in our lab! This study investigates the effects of 6-week administration with 8-herb extract on exercise performance and metabolism, antioxidant status and telomerase activity in healthy men. Supported by Bio Aktivátor Kft (Hong Kong), this interesting study will help us [...]
Nitrates for exercise performance
Nitrates for exercise performance Placebo-controlled trial at ABL We just started another randomized controlled trial that evaluates possible performance-enhancing effects of novel formulation with nitrates. Supported by ThermoLife International LLC, this interventional study assess does a single dose of advanced nitrate formula improves cardiorespiratory endurance and muscular strength in young men, using a double-blind, placebo-controlled, cross-over [...]
Vasodilation study in ABL
Vasodilation study in ABL Kick-off day for a new trial Today, we have started a new research study that compares vasodilating effects of several dietary supplements. This exciting double-blind, randomized, cross-over trail evaluates the effects of single-dose intervention with different dietary supplements on muscle blood flow and brachial artery diameter before, during and after exercise in [...]
New studies with hydrogen
New studies with hydrogen ABL trials for ankle sprain and alertness Few days ago, we started two studies with molecular hydrogen, with both trials partly supported by our long-established industry partner HRW Natural Health Products Inc. In the first trial, we evaluate the effects of single-dose hydrogen-rich water and caffeine for improving alertness in sleep-deprived healthy [...]
Carnosine for multiple sclerosis
Carnosine for multiple sclerosis Kick-off for an interventional trial with oral carnosine in multiple sclerosis This week, we have started a new interventional trial, evaluating the efficacy and safety of oral carnosine in patients with multiple sclerosis. During the next few months, we will evaluate does oral carnosine affect markers of brain bioenergetics and brain carnosine, [...]
Exercise and mitochondrial dysfunction
Exercise and mitochondrial dysfunction Link between heavy prolonged exercise, health and biomarkers of mitochondrial function in athletic population As part of our project Novel Biomarkers of Fatigue and Mitochondrial Dysfunction, supported by the Provincial Secretariat for Higher Education and Scientific Research (Grant No. 114-451-710), our team starts to evaluate a possible connection between the prevalence of [...]