Creatine precursor for muscle protein synthesis in elderly

Guanidinoacetic acid as a possible food for tackling sarcopenia

We have recently initiated a randomized controlled trial in our laboratory to evaluate the potential benefits of creatine and creatine analogs in older adults. Specifically, we aim to determine whether eight weeks of guanidinoacetic acid (GAA) supplementation offers superior effects compared to creatine on measures of muscle function and biomarkers of muscle protein synthesis in individuals aged 65 and older. Preliminary data suggest that GAA may exert anabolic and anti-catabolic effects through several mechanisms. In this study, we seek to further explore these effects in a sarcopenic population, which may particularly benefit from targeted dietary interventions addressing this widespread age-related condition.