A recent research demonstrated an impaired brain metabolism in chronic migraine patients with medication overuse headache. Besides other findings, reduced total creatine levels have been found in the left thalamus of 32 chronic migraine patients with and without medication.
Guanidinoacetic acid (GAA) is a naturally-occurring precursor of creatine and one of the key compounds investigated in our lab. GAA is found in human serum and urine, with circulating GAA likely reflects an equilibrium between its endogenous production and utilization/excretion.
Our long-time friend, patron and collaborator on nutraceuticals research Professor Dusan Miljkovic, PhD has died September 5, 2020 in San Diego, CA. Professor Miljkovic was a brilliant researcher, passionate entrepreneur, and a science polymath that illuminated many students and colleagues, including our lab staff and fellows.
Creatine plays a pivotal role in brain bioenergetics, acting as a temporal and spatial energy buffer, energy transducer, and metabolic regulator. A low cerebral creatine concentration illustrating energy depletion has been routinely observed in various neuropathologies,
Novel food for skeletal muscle GAA as functional additive Guanidinoacetic acid (GAA) is a direct endogenic precursor of creatine. GAA is also a re-discovered nutraceutical that has been put forward as an energy-facilitating compound by many animal and a few human studies. Recent trials indicated [...]
ABL won governmental research grant Keep studying mitochondria We just received a fantastic news from Provincial Government of Vojvodina that our research proposal "Dietary and Physiological Agents for Optimizing Mitochondrial Function" has been selected for funding! The Provincial Secretariat for Higher Education and Scientific Research [...]
Targeting AGAT in molecular nutrition Annals of Nutrition and Metabolism L-arginine:glycine amidinotransferase (AGAT) is a key enzyme in the biosynthesis of creatine, a natural amino acid derivative that plays a major role in temporal and spatial energy buffering. AGAT is a tissue-specific enzyme, predominantly expressed [...]
Hydrogen improves cognition in elderly New ABL paper in IJG Our research on hydrogen has just been published in a recent issue of International Journal of Gerontology! We analyzed here the impact of 4-week hydrogen gas inhalation on cognitive performance in thirteen women aged 65 [...]
2020 Annual Nutrition Science Meeting Seattle turns into ONLINE The American Society for Nutrition cancelled its in-person meeting, NUTRITION 2020, following escalating concerns regarding COVID-19. However, the ASN reinvents NUTRITION 2020 as a live online virtual meeting that is going to be organized from June [...]