We found here that the dietary exposure to GAA is relatively low among the US adults, with the average intake (∼10 mg/day) only contributes marginally to the total daily turnover of creatine.

Patients with SPMS may benefit from guanidinoacetate-creatine treatment in terms of patient- and clinician-reported outcomes; this requires additional study.

This unique piece of equipment is a new component of the biochemical arm of our lab, provided by a financial support of Provincial Secretariat for Higher Education and Scientific Research

Humans have to obtain enough creatine from the diet, which nominates creatine as an essential nutrient in certain circumstances.

Six-month HRW intake (0.5 L per day) favorably affected several aging-related features in healthy elderly. For instance, HRW extended mean telomere length by ~4% and tended to improve DNA methylation.

We will evaluate how low-dose creatine supplementation affects functional performance, tissue bioenergetics and clinical outcomes in men and women who developed post-covid-19 fatigue syndrome

No epidemiological studies so far evaluated the intake of creatine via regular diet in the elderly, neither the possible link between creatine consumption and risk of chronic medical conditions

GAA-creatine might be recognized as a nutritional intervention with the potential to tackle compromised tissue bioenergetics and functional impairments associated with aging.

Hydrogen could be recommended as a novel intervention that upholds attention in stressed conditions, with its metabolic footprint likely different from caffeine.

Dietary intake information from ten consecutive rounds of NHANES (from 1999 to 2000 to 2017-2018) was extracted for a total of 89,161 respondents aged 0-85 years. Individual values for total grams of creatine consumed per day were computed using the average amount of creatine (3.88 g/kg) across all creatine-containing food sources.