Creatine plays a pivotal role in brain bioenergetics, acting as a temporal and spatial energy buffer, energy transducer, and metabolic regulator. A low cerebral creatine concentration illustrating energy depletion has been routinely observed in various neuropathologies, including cerebrovascular diseases, brain neoplasms, inborn disorders of creatine metabolism, and age-related conditions. White matter disorders, however, appear to encounter a different dynamics in brain creatine variation that could be potentially useful in the disease screening and prognosis. Read more about this in new paper authored by Prof. Ostojic and published few days ago in Multiple Sclerosis and Related Disorders.