Creatine levels are rather sensitive to numerous conditions of the developing brain, including prematurity-related clinical complications. For instance, the presence of cerebellar injury in infants born prematurely was consistently associated with reduced concentrations of creatine (along with N-acetyl aspartate and choline), while cerebral cortical brain injury severity was inversely associated with both creatine and choline.
A recent research demonstrated an impaired brain metabolism in chronic migraine patients with medication overuse headache. Besides other findings, reduced total creatine levels have been found in the left thalamus of 32 chronic migraine patients with and without medication.
Guanidinoacetic acid (GAA) is a naturally-occurring precursor of creatine and one of the key compounds investigated in our lab. GAA is found in human serum and urine, with circulating GAA likely reflects an equilibrium between its endogenous production and utilization/excretion.
Our long-time friend, patron and collaborator on nutraceuticals research Professor Dusan Miljkovic, PhD has died September 5, 2020 in San Diego, CA. Professor Miljkovic was a brilliant researcher, passionate entrepreneur, and a science polymath that illuminated many students and colleagues, including our lab staff and fellows.
Kick off time for another RCT in elderly! This time, we aim to evaluate does 6-month supplementation with magnesium-powered hydrogen-rich water affect molecular and phenotypic biomarkers of aging. This ambitious trial, comprises various biomarkers of aging in men and women over 70 years, such as extensive blood biochemistry panel, brain metabolism, cognitive and physical function, even facial skin features, assessed both before and after the intervention in a magnesium-controlled parallel-group design.
Creatine plays a pivotal role in brain bioenergetics, acting as a temporal and spatial energy buffer, energy transducer, and metabolic regulator. A low cerebral creatine concentration illustrating energy depletion has been routinely observed in various neuropathologies,
Novel food for skeletal muscle GAA as functional additive Guanidinoacetic acid (GAA) is a direct endogenic precursor of creatine. GAA is also a re-discovered nutraceutical that has been put forward as an energy-facilitating compound by many animal and a few human studies. Recent trials indicated [...]
ABL won governmental research grant Keep studying mitochondria We just received a fantastic news from Provincial Government of Vojvodina that our research proposal "Dietary and Physiological Agents for Optimizing Mitochondrial Function" has been selected for funding! The Provincial Secretariat for Higher Education and Scientific Research [...]
Topical hydrogen in DOMS trial Questioning post-exercise recovery During the past few days, we started new trial evaluating the effects of topical hydrogen on biomarkers of delayed onset of muscle soreness (DOMS) after exhaustive eccentric exercise in young men. The small-scale double-blind placebo-controlled randomized trial [...]