Creatine plays a pivotal role in brain bioenergetics, acting as a temporal and spatial energy buffer, energy transducer, and metabolic regulator. A low cerebral creatine concentration illustrating energy depletion has been routinely observed in various neuropathologies,
Novel food for skeletal muscle GAA as functional additive Guanidinoacetic acid (GAA) is a direct endogenic precursor of creatine. GAA is also a re-discovered nutraceutical that has been put forward as an energy-facilitating compound by many animal and a few human studies. Recent trials indicated [...]
ABL won governmental research grant Keep studying mitochondria We just received a fantastic news from Provincial Government of Vojvodina that our research proposal "Dietary and Physiological Agents for Optimizing Mitochondrial Function" has been selected for funding! The Provincial Secretariat for Higher Education and Scientific Research [...]
Topical hydrogen in DOMS trial Questioning post-exercise recovery During the past few days, we started new trial evaluating the effects of topical hydrogen on biomarkers of delayed onset of muscle soreness (DOMS) after exhaustive eccentric exercise in young men. The small-scale double-blind placebo-controlled randomized trial [...]
Targeting AGAT in molecular nutrition Annals of Nutrition and Metabolism L-arginine:glycine amidinotransferase (AGAT) is a key enzyme in the biosynthesis of creatine, a natural amino acid derivative that plays a major role in temporal and spatial energy buffering. AGAT is a tissue-specific enzyme, predominantly expressed [...]
Hydrogen improves cognition in elderly New ABL paper in IJG Our research on hydrogen has just been published in a recent issue of International Journal of Gerontology! We analyzed here the impact of 4-week hydrogen gas inhalation on cognitive performance in thirteen women aged 65 [...]
2020 Annual Nutrition Science Meeting Seattle turns into ONLINE The American Society for Nutrition cancelled its in-person meeting, NUTRITION 2020, following escalating concerns regarding COVID-19. However, the ASN reinvents NUTRITION 2020 as a live online virtual meeting that is going to be organized from June [...]
ABL reopening Slow and careful restart After a break of over 4 weeks, our lab is reopening, following the guidelines from the National Institute of Health and internal ABL regulations. Hopefully, the full capacity of ABL will be re-established by early June but we already [...]
Overcoming restraints of creatine New paper in Trends in Food Science Creatine is arguably among the most popular dietary supplements of the XXI century. During the past two decades, this natural glycine derivative has been extensively investigated and practiced in sports nutrition, while recent trials [...]
Gut microbiota as a source of GAA ABL paper in Medical Hypotheses Guanidinoacetic acid (GAA) is an important intermediate in energy metabolism, acting as a precursor of creatine. Mainly synthesized by the human kidney, liver and pancreas, GAA might be produced by the gut microbiota [...]
