In a recent issue of Asian Journal of Psychiatry, we presented a pragmatic hypothesis that the inclusion of GAA might offer an additional benefit in profiling inflammation-oxidative stress in schizophrenia. GAA levels in the brain, cerebrospinal fluid, serum, and urine are responsive to various brain conditions.
Clinical applications of molecular hydrogen seem to favorably affect obesity-related metabolic biomarkers in peripheral tissues, yet whether H2 directly tackles obesity pathways in the brain remains elusive. We summarized several molecular targets in the hypothalamus and beyond that could be altered by H2 gas in obesity in a new paper just published in Trends in Endocrinology and Metabolism.
Our new paper published few days ago in Current Topics In Nutraceutical Research provides an update on specific nutraceuticals that are reported to modulate AGAT activity and discusses possible implications of targeting this enzyme in experimental and clinical nutrition.
Our paper on comparative molecular docking studies on creatine and guanidinoacetic acid (GAA) has been published in Journal of Chemical Research. Docking and density functional theory studies are carried out for muscle creatine kinase, and the changes in the geometries of the ligands before and after binding to the enzyme are investigated.
Our recent study published in Nutrition Research describes the effects of L-carnosine administration on various patient- and clinician-reported outcomes in a case series of patients with multiple sclerosis (MS). L-carnosine was administered orally for 8 weeks in two women and one man suffering from MS.
The book on bioenergetics edited by Professor Ostojic has just been published for Elsevier! Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics
We have continued scrutinization of L-carnosine in ABL! This time, we profile the single-dose pharmacokinetics of L-carnosine in healthy men in aim to compare the time course of its absorption, bioavailability, distribution, metabolism and excretion vs. traditional carnosine. The phase 0 study may help us to better determine the half-life of this nutritional additive and perhaps establish the most appropriate dosing regimen.
Creatine levels are rather sensitive to numerous conditions of the developing brain, including prematurity-related clinical complications. For instance, the presence of cerebellar injury in infants born prematurely was consistently associated with reduced concentrations of creatine (along with N-acetyl aspartate and choline), while cerebral cortical brain injury severity was inversely associated with both creatine and choline.
A recent research demonstrated an impaired brain metabolism in chronic migraine patients with medication overuse headache. Besides other findings, reduced total creatine levels have been found in the left thalamus of 32 chronic migraine patients with and without medication.
Guanidinoacetic acid (GAA) is a naturally-occurring precursor of creatine and one of the key compounds investigated in our lab. GAA is found in human serum and urine, with circulating GAA likely reflects an equilibrium between its endogenous production and utilization/excretion.