About Sergej Ostojic

This author has not yet filled in any details.
So far Sergej Ostojic has created 54 blog entries.

Targeting the brain with hydrogen

2021-02-05T11:24:13+01:00February 5th, 2021|News|

Clinical applications of molecular hydrogen seem to favorably affect obesity-related metabolic biomarkers in peripheral tissues, yet whether H2 directly tackles obesity pathways in the brain remains elusive. We summarized several molecular targets in the hypothalamus and beyond that could be altered by H2 gas in obesity in a new paper just published in Trends in Endocrinology and Metabolism.

Clinical Bioenergetics – 1st Edition

2021-01-30T14:08:38+01:00December 2nd, 2020|News|

The book on bioenergetics edited by Professor Ostojic has just been published for Elsevier! Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics

L-carnosine PK study

2020-11-17T17:30:22+01:00November 17th, 2020|On-going research|

We have continued scrutinization of L-carnosine in ABL! This time, we profile the single-dose pharmacokinetics of L-carnosine in healthy men in aim to compare the time course of its absorption, bioavailability, distribution, metabolism and excretion vs. traditional carnosine. The phase 0 study may help us to better determine the half-life of this nutritional additive and perhaps establish the most appropriate dosing regimen.

Brain creatine in preterm children

2020-11-05T23:27:52+01:00November 7th, 2020|News|

Creatine levels are rather sensitive to numerous conditions of the developing brain, including prematurity-related clinical complications. For instance, the presence of cerebellar injury in infants born prematurely was consistently associated with reduced concentrations of creatine (along with N-acetyl aspartate and choline), while cerebral cortical brain injury severity was inversely associated with both creatine and choline.

Go to Top