June 28th, 2020
L-arginine: glycine amidinotransferase (AGAT) is a key enzyme in the biosynthesis of creatine and it's upregulation is a possible target in molecular nutrition.
July 22nd, 2020
Our research proposal “Dietary and Physiological Agents for Optimizing Mitochondrial Function” has been selected for funding!
November 5, 2019
In our new paper, published in journal Physiological Research few days ago, we evaluated changes in serum GAA among healthy women aged 18 to 65 years.
December 5, 2019
Have you ever had a dream that that the oldest element in the Universe can help you to run better? We confirmed just that – gaseous hydrogen appears to be effective to improve various exercise performance outcomes in young men and women.
March 3, 2020
We have started another double-blind RCT in our lab! This study investigates the effects of 6-week administration with 8-herb extract on exercise performance and metabolism, antioxidant status and telomerase activity in healthy men.
Applied Bioenergetics Lab
Advancing Science for Healthier Life
Disturbances in cellular energy homeostasis are considered a key element of different conditions – from cardiometabolic and neurodegenerative diseases to athletic performance and aging, with improving bioenergetics remains a challenging task for both industry and academia.
Here in Applied Bioenergetics Lab, we strive to advance novel dietary supplements and similar therapeutics that protect and restore tissue bioenergetics and metabolism in health and disease, by joint our forces with different partners.
Our lab is one of the most active research units at UNS, publishing 12-15 scientific articles per year in premier journals. Stay informed about our activities by clicking on the links below!
Latest news
Clinical Bioenergetics – 1st Edition
Clinical Bioenergetics | 1st Edition ABL book for Elsevier The book on bioenergetics edited by Professor Ostojic has just been published for Elsevier! Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology [...]
L-carnosine PK study
We have continued scrutinization of L-carnosine in ABL! This time, we profile the single-dose pharmacokinetics of L-carnosine in healthy men in aim to compare the time course of its absorption, bioavailability, distribution, metabolism and excretion vs. traditional carnosine. The phase 0 study may help us to better determine the half-life of this nutritional additive and perhaps establish the most appropriate dosing regimen.
Brain creatine in preterm children
Creatine levels are rather sensitive to numerous conditions of the developing brain, including prematurity-related clinical complications. For instance, the presence of cerebellar injury in infants born prematurely was consistently associated with reduced concentrations of creatine (along with N-acetyl aspartate and choline), while cerebral cortical brain injury severity was inversely associated with both creatine and choline.
GAA deficiency in clinical medicine
Guanidinoacetic acid (GAA) is a naturally-occurring precursor of creatine and one of the key compounds investigated in our lab. GAA is found in human serum and urine, with circulating GAA likely reflects an equilibrium between its endogenous production and utilization/excretion.
In memoriam
Our long-time friend, patron and collaborator on nutraceuticals research Professor Dusan Miljkovic, PhD has died September 5, 2020 in San Diego, CA. Professor Miljkovic was a brilliant researcher, passionate entrepreneur, and a science polymath that illuminated many students and colleagues, including our lab staff and fellows.