Applied Bioenergetics Lab
Advancing Science for Healthier Life
Disturbances in cellular energy homeostasis are considered a key element of different conditions – from cardiometabolic and neurodegenerative diseases to athletic performance and aging, with improving bioenergetics remains a challenging task for both industry and academia.
Here in Applied Bioenergetics Lab, we strive to advance novel dietary supplements and similar therapeutics that protect and restore tissue bioenergetics and metabolism in health and disease, by joint our forces with different partners.
Our lab is one of the most active research units at UNS, publishing 12-15 scientific articles per year in premier journals. Stay informed about our activities by clicking on the links below!
Latest news
Guanidinoacetic acid changes in schizophrenia
In a recent issue of Asian Journal of Psychiatry, we presented a pragmatic hypothesis that the inclusion of GAA might offer an additional benefit in profiling inflammation-oxidative stress in schizophrenia. GAA levels in the brain, cerebrospinal fluid, serum, and urine are responsive to various brain conditions.
Targeting the brain with hydrogen
Clinical applications of molecular hydrogen seem to favorably affect obesity-related metabolic biomarkers in peripheral tissues, yet whether H2 directly tackles obesity pathways in the brain remains elusive. We summarized several molecular targets in the hypothalamus and beyond that could be altered by H2 gas in obesity in a new paper just published in Trends in Endocrinology and Metabolism.
Nutraceuticals for AGAT Modulation
Our new paper published few days ago in Current Topics In Nutraceutical Research provides an update on specific nutraceuticals that are reported to modulate AGAT activity and discusses possible implications of targeting this enzyme in experimental and clinical nutrition.
Docking studies on creatine and GAA
Our paper on comparative molecular docking studies on creatine and guanidinoacetic acid (GAA) has been published in Journal of Chemical Research. Docking and density functional theory studies are carried out for muscle creatine kinase, and the changes in the geometries of the ligands before and after binding to the enzyme are investigated.
New paper in Nutrition Research
Our recent study published in Nutrition Research describes the effects of L-carnosine administration on various patient- and clinician-reported outcomes in a case series of patients with multiple sclerosis (MS). L-carnosine was administered orally for 8 weeks in two women and one man suffering from MS.