Aging is often characterized by mild ognitive impairment ( MCI), a noticeable and measurable decline in cognitive abilities, including memory and thinking skills. MCI is accompanied by a reduction in brain energy metabolism, with lower-level bioenergetics goes with more detrimental clinical outcomes. A person with MCI is also at higher risk of developing Alzheimer’s disease, the most frequent cause of dementia in developed countries.
Our goal here is to identify the best possible compounds that are able to get to this difficult-to-reach organ by targeting uncommon cell transporters, and to test their potency and pharmacovigilance to tackle low bioenergetics in aging brain.
Sarcopenia is a highly prevalent age-related degenerative loss of skeletal muscle mass, quality, and strength, all leading to adverse health issues and disability in elderly. Sarcopenic muscle appears to show diminished capacity to utilize creatine, a key amino acid derivative in cellular energetics.
We conceive and evaluate the efficacy of several tissue-specific organic compounds, including active creatine analogs, to improve muscle bioenergetics, and perhaps help elderly to minimize or postpone detrimental consequences of the aging process.
Non-alcoholic fatty liver disease ( NAFLD) is a metabolic disorder characterized by liver fat deposition, with up to 30% of population in developed countries have this perplexing condition. Metabolic impairment of the liver and mitochondrial dysfunction of this energy-demanding organ play significant roles in NAFLD pathogenesis.
Therefore, advancing liver energy metabolism via specific agents (such as inhalational molecular hydrogen or oral nucleotides) might be appropriate to tackle this complex condition.
It seems that inadequate or impaired energy provision through cellular metabolism may contribute to the pathogenic initiation and maintenance of chronic fatigue syndrome ( CFS), a debilitating medical condition characterized by profound fatigue of unknown cause. In many cases, CFS is permanent and limits the patient’s functional capacity, producing various degrees of disability, while there is no cure or approved treatment for CFS.
We investigate here how energy-related compounds tackle low bioenergetics and major symptoms in CFS, thus searching for a possible adjuvant or supplementary treatment for this medical condition.
Multi-year heavy prolonged exercise appears to induce mitochondrial dysfunction and impaired bioenergetics, while demonstrating several features of overtraining syndrome, cardiovascular irregularities, overuse injuries or immune system disorders.
We work to find an upper-end threshold above which exercise becomes more hazardous in terms of health, but also to establish a reliable biomarker of exercise-induced mitochondrial dysfunction (EIMD) and ultimately to search out for valuable therapeutics that prevent and manage this puzzling malaise.
Superior performance in many sports appears to be linked with a provision and upkeep of readily available energy needed to sustain muscular work.
Although several peformance-enhancing substances that target cellular bioenergetics are already at hand, we keep searching for innovative mitochondria-related agents that might impove athletic and work capacity, but also redesigning established compounds for boosted bioavailability, ease of use and safety. We are also focused to creatine-related compounds, from creatine precursors, analogs and specific salts, to CRT1 and CRT2 agonists, and complex formulations.